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Colonel Henry Wilson was born February 16, 1812 in Farmingham, New Hampshire. He moved to Natick, Massachusetts in 1833. In 1840 he was a members of the Legislature and was generally known as "The Natick Cobbler," in reference to his humble occupation. He was in the State Senate in 1844, 1845 and 1850, a candidate for Governor in 1853 and chosen to the United States Senate in 1855. He was continuously in the Senate until 1872 when he was elected Vice-President of the United States. He died in office on November 22, 1875. He was the first colonel of the 22nd Massachusetts, serving from September 2 to October 29, 1861.
Colonel Jesse Gove was born December 5, 1824 at Ware, New Hampshire. He was educated at the Military Academy at Norwich, Vermont. In 1847 he was appointed 2nd lieutenant in the 9th United States Infantry, served in the Mexican War, and was promoted to 1st lieutenant. At the close of the war, he took up the study of law and was admitted to the bar in 1851. From 1850 to 1855 he was Deputy Secretary of State for New Hampshire. In 1855, he was commissioned captain of Company I, Tenth United States Infantry, and was on frontier duty until the outbreak of the Rebellion. He was then ordered to Washington and succeeded Colonel Wilson in command of the 22nd. He was killed in action at Gaines Mill, Virginia, June 27, 1862.

Colonel Charles E. Griswold was the first lieutenant-colonel of the Twenty-second, and on the death of Col. Gove, was promoted to the command of the regiment. During the greater part of his connection with the Twenty-second he was in poor health, and he resigned Oct. 16, 1862. When the Fifty-sixth Regiment was raised, he was commissioned its colonel, July 14, 1863, and was killed in action May 6, 1864, at the age of twenty-nine.

Colonel William S. Tilton was born in Newburyport, Massachusetts on February 1, 1828. He was commissioned 1st lieutenant and adjutant, September 12, 1861 and rose through the ranks until he was appointed Colonel of the 22nd in September 1862. He would eventually receive the brevet rank of brigadier general. He was shot through the right shoulder at the Battle of Gaines Mill and was taken prisoner. He was paroled in July 1862 and returned to the 22nd in September to take command in place of Col. Griswold.

Colonel Mason W. Burt was born in Taunton, May 19, 1839. He was first sergeant of Company G, 4th MVI, in the three months campaign, and was in action at Big Bethel. He joined the Twenty-second as captain of Company C, which was color company. He was promoted major, Oct. 2, 1862; brevet colonel, Oct. 4, 1864. He commanded the regiment during a large portion of its latter term of service. Colonel of Third Regiment, MVI, 1866 - 1868. He now [ 1887] resides at Steubenville, O.

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